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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: EIF2S2 (NCBI Gene ID:8894)

Gene Summary

Gene Summary

Gene Information	Gene Name: EIF2S2
	Gene ID: 8894
	Gene Symbol	EIF2S2
	Gene ID	8894
	Gene Name	eukaryotic translation initiation factor 2 subunit beta
	Synonyms	EIF2\|EIF2B\|EIF2beta\|PPP1R67\|eIF-2-beta
	Cytomap	20q11.22
	Type of Gene	protein-coding
	Description	eukaryotic translation initiation factor 2 subunit 2eukaryotic translation initiation factor 2, subunit 2 beta, 38kDaprotein phosphatase 1, regulatory subunit 67
	Modification date	20200313
	UniProtAcc	P20042

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006417	Regulation of translation
GO:0008135	Translation factor activity, RNA binding
GO:0002181	Cytoplasmic translation
GO:0006413	Translational initiation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
EIF2S2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'EIF2S2[title] AND translation [title] AND human.'

Gene	Title	PMID
EIF2S2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000374980	32678322	32678408	Frame-shift
ENST00000374980	32681480	32681537	In-frame
ENST00000374980	32686303	32686439	Frame-shift
ENST00000374980	32691267	32691371	Frame-shift

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000374980	32681480	32681537	2673	906	962	333	228	246

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
P20042	228	246	2	333	Chain	ID=PRO_0000137406;Note=Eukaryotic translation initiation factor 2 subunit 2

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
KICH	EIF2S2	-1.06278646532411	0.00308787822723389
BRCA	EIF2S2	-2.57303037687825	1.70212120584918e-09
STAD	EIF2S2	-2.13186277769467	3.17529775202275e-05

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type

Gene

miRNA

TargetScan binding score (Context++ score percentile)

Coefficient

Pvalue

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
THCA	EIF2S2	0.174464216	0.046417225

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with EIF2S2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
COAD	Cell metabolism gene	EIF2S2	RPN2	0.818001239	1.57E-80
COAD	Cell metabolism gene	EIF2S2	PFDN4	0.825515277	3.10E-83
COAD	Cell metabolism gene	EIF2S2	AHCY	0.829661324	8.75E-85
COAD	Cell metabolism gene	EIF2S2	DPM1	0.864713446	8.17E-100
COAD	Cell metabolism gene	EIF2S2	RAE1	0.865170333	4.89E-100
COAD	Cell metabolism gene	EIF2S2	PSMA7	0.874382327	1.02E-104
COAD	IUPHAR	EIF2S2	TP53RK	0.810407452	6.38E-78
COAD	IUPHAR	EIF2S2	AHCY	0.829661324	8.75E-85
COAD	Kinase	EIF2S2	TP53RK	0.810407452	6.38E-78
DLBC	Cell metabolism gene	EIF2S2	EBP	0.803198918	6.46E-12
DLBC	Cell metabolism gene	EIF2S2	SNRPB	0.814040278	1.99E-12
DLBC	Cell metabolism gene	EIF2S2	PSMC3	0.818558194	1.19E-12
DLBC	Cell metabolism gene	EIF2S2	PSMA4	0.818681823	1.17E-12
DLBC	Cell metabolism gene	EIF2S2	PSMD8	0.822192165	7.79E-13
DLBC	Cell metabolism gene	EIF2S2	PSMA7	0.84014165	8.27E-14
DLBC	Cell metabolism gene	EIF2S2	TIMM50	0.842383023	6.13E-14
DLBC	Cell metabolism gene	EIF2S2	PSMB7	0.858207252	6.44E-15
DLBC	Cell metabolism gene	EIF2S2	TIMM10	0.871331751	7.99E-16
DLBC	CGC	EIF2S2	U2AF1	0.806426396	4.58E-12
DLBC	TSG	EIF2S2	PHB	0.828911482	3.47E-13
READ	Cell metabolism gene	EIF2S2	RPN2	0.800533514	1.22E-24
READ	Cell metabolism gene	EIF2S2	PSMA7	0.843580141	1.43E-29
READ	Cell metabolism gene	EIF2S2	AHCY	0.844964929	9.37E-30
READ	Cell metabolism gene	EIF2S2	RAE1	0.849005418	2.68E-30
READ	Cell metabolism gene	EIF2S2	MOCS3	0.855895017	2.90E-31
READ	IUPHAR	EIF2S2	AHCY	0.844964929	9.37E-30
READ	IUPHAR	EIF2S2	TP53RK	0.84634291	6.14E-30
READ	Kinase	EIF2S2	TP53RK	0.84634291	6.14E-30
TGCT	Cell metabolism gene	EIF2S2	SNRPD1	0.800554244	4.52E-36
TGCT	CGC	EIF2S2	HMGA1	0.83115177	4.30E-41
TGCT	IUPHAR	EIF2S2	MFSD2B	0.808943189	2.34E-37
TGCT	TF	EIF2S2	HMGA1	0.83115177	4.30E-41
TGCT	TSG	EIF2S2	PHB	0.85455881	1.14E-45
THYM	Cell metabolism gene	EIF2S2	SNRPD1	0.800678199	1.80E-28
THYM	Cell metabolism gene	EIF2S2	RAE1	0.803515962	8.34E-29
THYM	Cell metabolism gene	EIF2S2	PSME1	0.804841685	5.80E-29
THYM	Cell metabolism gene	EIF2S2	CCT7	0.805873822	4.36E-29
THYM	Cell metabolism gene	EIF2S2	SEC61G	0.807443466	2.82E-29
THYM	Cell metabolism gene	EIF2S2	PSMA5	0.807491592	2.78E-29
THYM	Cell metabolism gene	EIF2S2	IDH3B	0.815537829	2.77E-30
THYM	Cell metabolism gene	EIF2S2	SNRPB	0.819784888	7.85E-31
THYM	Cell metabolism gene	EIF2S2	POLR3K	0.8262332	1.08E-31
THYM	Cell metabolism gene	EIF2S2	DTYMK	0.831576858	1.97E-32
THYM	Cell metabolism gene	EIF2S2	FDPS	0.833816075	9.45E-33
THYM	Cell metabolism gene	EIF2S2	NOP56	0.860029468	7.23E-37
THYM	Cell metabolism gene	EIF2S2	PSMA7	0.864602512	1.14E-37
THYM	Cell metabolism gene	EIF2S2	SNRPE	0.87353431	2.50E-39
THYM	CGC	EIF2S2	CDK4	0.813756261	4.66E-30
THYM	Epifactor	EIF2S2	RUVBL1	0.80056686	1.86E-28
THYM	Epifactor	EIF2S2	HDGF	0.813922857	4.44E-30
THYM	Epifactor	EIF2S2	ENY2	0.824950479	1.61E-31
THYM	IUPHAR	EIF2S2	UCHL3	0.801510037	1.44E-28
THYM	IUPHAR	EIF2S2	CDK4	0.813756261	4.66E-30
THYM	IUPHAR	EIF2S2	FDPS	0.833816075	9.45E-33
THYM	IUPHAR	EIF2S2	ECE2	0.847383327	8.74E-35
THYM	Kinase	EIF2S2	CDK4	0.813756261	4.66E-30
UCS	Cell metabolism gene	EIF2S2	SNRPD1	0.800678199	1.80E-28
UCS	Cell metabolism gene	EIF2S2	RAE1	0.803515962	8.34E-29
UCS	Cell metabolism gene	EIF2S2	PSME1	0.804841685	5.80E-29
UCS	Cell metabolism gene	EIF2S2	CCT7	0.805873822	4.36E-29
UCS	Cell metabolism gene	EIF2S2	SEC61G	0.807443466	2.82E-29
UCS	Cell metabolism gene	EIF2S2	PSMA5	0.807491592	2.78E-29
UCS	Cell metabolism gene	EIF2S2	IDH3B	0.815537829	2.77E-30
UCS	Cell metabolism gene	EIF2S2	SNRPB	0.819784888	7.85E-31
UCS	Cell metabolism gene	EIF2S2	POLR3K	0.8262332	1.08E-31
UCS	Cell metabolism gene	EIF2S2	DTYMK	0.831576858	1.97E-32
UCS	Cell metabolism gene	EIF2S2	FDPS	0.833816075	9.45E-33
UCS	Cell metabolism gene	EIF2S2	NOP56	0.860029468	7.23E-37
UCS	Cell metabolism gene	EIF2S2	PSMA7	0.864602512	1.14E-37
UCS	Cell metabolism gene	EIF2S2	SNRPE	0.87353431	2.50E-39
UCS	CGC	EIF2S2	CDK4	0.813756261	4.66E-30
UCS	Epifactor	EIF2S2	RUVBL1	0.80056686	1.86E-28
UCS	Epifactor	EIF2S2	HDGF	0.813922857	4.44E-30
UCS	Epifactor	EIF2S2	ENY2	0.824950479	1.61E-31
UCS	IUPHAR	EIF2S2	UCHL3	0.801510037	1.44E-28
UCS	IUPHAR	EIF2S2	CDK4	0.813756261	4.66E-30
UCS	IUPHAR	EIF2S2	FDPS	0.833816075	9.45E-33
UCS	IUPHAR	EIF2S2	ECE2	0.847383327	8.74E-35
UCS	Kinase	EIF2S2	CDK4	0.813756261	4.66E-30
UVM	Cell metabolism gene	EIF2S2	NUPL2	0.800298757	5.27E-19
UVM	Cell metabolism gene	EIF2S2	DPM1	0.804357268	2.57E-19
UVM	Cell metabolism gene	EIF2S2	MED7	0.833331162	8.91E-22
UVM	Cell metabolism gene	EIF2S2	SRP19	0.846928856	4.24E-23
UVM	Cell metabolism gene	EIF2S2	GRPEL2	0.847322679	3.86E-23
UVM	Epifactor	EIF2S2	VRK1	0.800108453	5.44E-19
UVM	Epifactor	EIF2S2	TLK1	0.803983627	2.75E-19
UVM	Epifactor	EIF2S2	CDK7	0.815152904	3.50E-20
UVM	Epifactor	EIF2S2	TAF9	0.844705444	7.11E-23
UVM	IUPHAR	EIF2S2	VRK1	0.800108453	5.44E-19
UVM	IUPHAR	EIF2S2	TLK1	0.803983627	2.75E-19
UVM	IUPHAR	EIF2S2	CDK7	0.815152904	3.50E-20
UVM	IUPHAR	EIF2S2	CSNK1G3	0.81913895	1.62E-20
UVM	IUPHAR	EIF2S2	CSNK1A1	0.824823513	5.23E-21
UVM	IUPHAR	EIF2S2	RIOK2	0.837304743	3.77E-22
UVM	Kinase	EIF2S2	VRK1	0.800108453	5.44E-19
UVM	Kinase	EIF2S2	TLK1	0.803983627	2.75E-19
UVM	Kinase	EIF2S2	CDK7	0.815152904	3.50E-20
UVM	Kinase	EIF2S2	CSNK1G3	0.81913895	1.62E-20
UVM	Kinase	EIF2S2	CSNK1A1	0.824823513	5.23E-21
UVM	Kinase	EIF2S2	RIOK2	0.837304743	3.77E-22
UVM	TF	EIF2S2	CEBPZ	0.802061283	3.86E-19
UVM	TF	EIF2S2	ZNF140	0.808437248	1.23E-19
UVM	TF	EIF2S2	GPBP1	0.830469911	1.63E-21
UVM	TSG	EIF2S2	RBBP8	0.804708413	2.41E-19
UVM	TSG	EIF2S2	CSNK1A1	0.824823513	5.23E-21

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
LIHC	EIF2S2	EIF2B5	-2.17335102876885	0.000112780019881286
KICH	EIF2S2	EIF2B3	2.17795043401278	0.000216901302337646
HNSC	EIF2S2	EIF1	-4.13399438210909	0.000228392819053625
PRAD	EIF2S2	EIF3A	1.13680328391952	0.000363360004697762
THCA	EIF2S2	EIF2B3	-2.27193247701228	0.000372452864704637
BRCA	EIF2S2	EIF5	-1.16704316213885	0.00107943958337404
LIHC	EIF2S2	EIF2S3	-4.62530933210412	0.00154404530385922
HNSC	EIF2S2	EIF2B3	-1.66956934127194	0.00459462782941955
KIRP	EIF2S2	EIF3G	-2.4178322962129	0.00471024587750435
BLCA	EIF2S2	EIF3A	-4.45104058307747	0.00532913208007812
PRAD	EIF2S2	EIF1	1.32822648991353	0.00674237731133815
COAD	EIF2S2	EIF2B3	-1.60183733464354	0.00938254594802858
COAD	EIF2S2	EIF2B5	-3.82949281161428	0.011966735124588
UCEC	EIF2S2	EIF3G	-3.35078334696571	0.03125
BLCA	EIF2S2	EIF3G	-3.07707559649091	0.0323410034179688
STAD	EIF2S2	EIF2B1	1.06970835543362	0.0324882394634187
ESCA	EIF2S2	EIF2S3	-1.31322237574718	0.0419921875
LUAD	EIF2S2	EIF3B	-5.80435587546762	1.0542655358657e-09
BRCA	EIF2S2	EIF3G	1.87948385011271	1.9107949115022e-06
KIRC	EIF2S2	EIF3B	-1.56313263784517	2.35252849767166e-12
STAD	EIF2S2	EIF3B	-4.7724660972007	3.25962901115418e-08
HNSC	EIF2S2	EIF3B	2.6202554263604	4.48234413852334e-06
KIRP	EIF2S2	EIF3B	-2.7592297042974	4.6566128730774e-09
LIHC	EIF2S2	EIF5	-2.12060405382854	4.66164898670786e-08
KIRP	EIF2S2	EIF2B1	-2.14953108463177	5.24520874023438e-06
LUAD	EIF2S2	EIF2B1	-2.39668434561352	5.70558004016916e-06
BRCA	EIF2S2	EIF2B3	-1.42398409637427	6.27134207487183e-10
BRCA	EIF2S2	EIF3A	-1.218215573148	7.39403582934137e-06
KIRC	EIF2S2	EIF2B1	-1.83635928054145	7.43306349049898e-12

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with EIF2S2

PLEKHM1, CRMP1, KIAA1377, ZBTB16, APLP1, CCDC90B, TLE1, TP53, UNC119, EIF5, PRKDC, Eif5, H2AFX, DCC, HDGF, CAND1, APP, EIF2S1, PAXIP1, CSNK2A1, CSNK2B, UPF1, MMS19, HMGA1, GCN1L1, rev, RPA3, RPA2, RPA1, SUZ12, RNF2, MAST3, ESR1, KLHL20, MBD5, SERPINB5, HOXB5, ZCCHC7, EIF2S3, PRMT7, CDC123, ETFA, RNF26, CYP1A1, RPS6KB2, DDX56, ATAD3B, CDC5L, ETF1, FBL, MRTO4, MYL9, SUB1, KIF23, NCAPD3, NEMF, NOP56, NOP58, NSA2, RPL15, RPL37A, NTRK1, NCK1, XPO1, COPS7A, EXOSC4, EXOSC1, Rrbp1, Ksr1, FAU, UBA52, EIF5A, RPS19, RPS12, RPS10, NPM1, RAN, ATP5C1, VAT1, PA2G4, STIP1, CYLD, TRIM25, G3BP1, GSK3A, PCBP1, RAD18, PRPF8, EFTUD2, TNIP2, RIOK1, AGR2, RECQL4, MYC, RAB11A, RAB9A, BET1, TUBA1A, TOMM20, SFXN1, TOMM22, AURKAIP1, METTL14, PHB, MAPT, USP14, NR2C2, UBQLN2, MTDH, NHLRC2, KRAS, DDX60, SNRNP70, Dppa3, CDC14A, PTPN6, BIRC3, STAU1, NFX1, BRD7, TRIM28, CMTR1, CUL7, PLEKHA4, HCVgp1, ZC3H18, MAP4K1, PRKCB, KTN1, CIT, MAD2L2, C12orf49, INS, BRD4, NUPR1, Apc2, nsp15, USP10, OGT, CD274, TULP3, UFL1, DDRGK1, FZR1, WDR5, TOR1B, FBXW7, M, nsp16, nsp4, ORF10, ORF7a, ORF8, N,

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Mutations

Clinically associated variants from ClinVar.

Gene	Chr	Position	RefSeq	VarSeq	RefSeeq	VarType	Pathogenic	Disease	VarInfo
EIF2S2	chr20	32677551	A	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2S2	chr20	32685228	G	A	single_nucleotide_variant	Benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant
EIF2S2	chr20	32693235	C	G	single_nucleotide_variant	Likely_benign	not_provided	SO:0001819\|synonymous_variant	SO:0001819\|synonymous_variant

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
EIF2S2	COAD	chr20	32684576	32684576	C	A	Missense_Mutation	p.K190N	5
EIF2S2	BRCA	chr20	32685285	32685285	G	C	Missense_Mutation	p.I157M	4
EIF2S2	UCEC	chr20	32693352	32693352	C	A	Splice_Site	e2-1	4
EIF2S2	DLBC	chr20	32677684	32677684	C	T	Missense_Mutation	p.R285Q	3
EIF2S2	UCEC	chr20	32677652	32677652	G	C	Missense_Mutation	p.R296G	3
EIF2S2	LIHC	chr20	32693175	32693175	T	-	Splice_Site	p.K64_splice	3
EIF2S2	SARC	chr20	32684518	32684518	C	T	Missense_Mutation	p.V210I	3
EIF2S2	UCS	chr20	32677668	32677668	G	A	Silent	p.I290I	2
EIF2S2	HNSC	chr20	32677564	32677564	C	T	Missense_Mutation	p.R325Q	2
EIF2S2	THCA	chr20	32677564	32677564	C	G	Missense_Mutation	p.R325P	2
EIF2S2	HNSC	chr20	32693175	32693175	T	-	Frame_Shift_Del	p.K64fs	2
EIF2S2	HNSC	chr20	32677564	32677564	C	T	Missense_Mutation		2
EIF2S2	UCEC	chr20	32681530	32681530	G	A	Missense_Mutation	p.R231C	2
EIF2S2	LIHC	chr20	32677592	32677592	T	-	Frame_Shift_Del	p.T316fs	2
EIF2S2	UCEC	chr20	32684501	32684501	C	A	Missense_Mutation	p.K215N	2
EIF2S2	BRCA	chr20	32678367	32678367	C	T	Missense_Mutation	p.R261K	2
EIF2S2	UCEC	chr20	32684509	32684509	C	T	Missense_Mutation	p.G213R	2
EIF2S2	UCEC	chr20	32684602	32684602	G	A	Nonsense_Mutation	p.R182*	2
EIF2S2	HNSC	chr20	32685311	32685311	C	A	Nonsense_Mutation	p.E149*	2
EIF2S2	CESC	chr20	32686316	32686316	C	G	Missense_Mutation		2
EIF2S2	STAD	chr20	32677677	32677677	C	T	Silent	p.P287P	2
EIF2S2	HNSC	chr20	32686339	32686339	A	G	Missense_Mutation	p.F133S	1
EIF2S2	LUAD	chr20	32684606	32684606	C	T	Silent	p.L180L	1
EIF2S2	CESC	chr20	32686316	32686316	C	G	Missense_Mutation	p.E141Q	1
EIF2S2	STAD	chr20	32693225	32693225	G	A	Missense_Mutation	p.P48S	1
EIF2S2	LUSC	chr20	32677584	32677584	G	T	Missense_Mutation	p.F318L	1
EIF2S2	COAD	chr20	32678368	32678368	T	G	Silent	p.R261R	1
EIF2S2	STAD	chr20	32677651	32677651	C	T	Missense_Mutation	p.R296Q	1
EIF2S2	HNSC	chr20	32685276	32685276	A	G	Silent	p.S160S	1
EIF2S2	OV	chr20	32156956	32156956	C	T	Missense_Mutation	p.M24I	1
EIF2S2	BLCA	chr20	32677681	32677681	G	A	Missense_Mutation		1
EIF2S2	PCPG	chr20	32691357	32691357	G	C	Missense_Mutation	p.L70V	1
EIF2S2	THYM	chr20	32686326	32686326	A	G	Silent		1
EIF2S2	KIRC	chr20	32699916	32699916	T	A	Translation_Start_Site	p.M1L	1
EIF2S2	BLCA	chr20	32684519	32684519	G	A	Silent		1
EIF2S2	SARC	chr20	32686422	32686422	A	G	Silent		1
EIF2S2	GBM	chr20	32677582	32677582	T	C	Missense_Mutation	p.Q319R	1
EIF2S2	LIHC	chr20	32686360	32686360	T	C	Missense_Mutation	p.K126R	1
EIF2S2	BLCA	chr20	32677681	32677681	G	A	Missense_Mutation	p.S286L	1
EIF2S2	SARC	chr20	32684518	32684518	C	T	Missense_Mutation		1
EIF2S2	BLCA	chr20	32684519	32684519	G	A	Silent	p.V209V	1
EIF2S2	SARC	chr20	32677559	32677559	G	T	Missense_Mutation		1
EIF2S2	HNSC	chr20	32685276	32685276	A	G	Silent		1
EIF2S2	SARC	chr20	32686422	32686422	A	G	Silent	p.S105S	1
EIF2S2	HNSC	chr20	32686339	32686339	A	G	Missense_Mutation		1
EIF2S2	LIHC	chr20	32678354	32678354	T	-	Frame_Shift_Del	p.K265fs	1
EIF2S2	LUAD	chr20	32677568	32677568	T	C	Missense_Mutation	p.K324E	1
EIF2S2	SKCM	chr20	32693176	32693176	T	C	Missense_Mutation	p.K64R	1
EIF2S2	HNSC	chr20	32677565	32677565	G	A	Nonsense_Mutation	p.R325*	1
EIF2S2	LUAD	chr20	32677589	32677589	C	T	Missense_Mutation	p.G317S	1
EIF2S2	CESC	chr20	32686325	32686325	C	A	Nonsense_Mutation		1

Copy number variation (CNV) of EIF2S2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across EIF2S2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102663	N/A	BU543690	APLP2	chr11	129991623	+	EIF2S2	chr20	32693280	-
102663	BLCA	TCGA-GV-A40E	ARIH1	chr15	72767355	+	EIF2S2	chr20	32693351	-
102663	CESC	TCGA-DS-A7WH-01A	ASXL1	chr20	30956926	+	EIF2S2	chr20	32693351	-
102663	BLCA	TCGA-XF-A8HG-01A	C20orf194	chr20	3230807	-	EIF2S2	chr20	32680685	-
102663	BLCA	TCGA-XF-A8HG-01A	C20orf194	chr20	3231820	-	EIF2S2	chr20	32678408	-
102663	READ	TCGA-AH-6903	CBFA2T2	chr20	32078107	+	EIF2S2	chr20	32693351	-
25750	LUSC	TCGA-LA-A7SW	EIF2S2	chr20	32678322	-	ADRA1D	chr20	4202777	-
25750	LUSC	TCGA-LA-A7SW	EIF2S2	chr20	32681481	-	ADRA1D	chr20	4202777	-
25750	LUSC	TCGA-LA-A7SW-01A	EIF2S2	chr20	32678323	-	ADRA1D	chr20	4202777	-
93554	BRCA	TCGA-C8-A273	EIF2S2	chr20	32699901	-	DEFB123	chr20	30037831	+
93554	BRCA	TCGA-C8-A273-01A	EIF2S2	chr20	32699902	-	DEFB123	chr20	30037832	+
93646	N/A	BI862538	EIF2S2	chr20	32677246	-	DENND1C	chr19	6471137	-
57030	N/A	BU571077	EIF2S2	chr20	32700004	-	ENSA	chr1	150595036	-
79996	STAD	TCGA-MX-A666-01A	EIF2S2	chr20	32691268	-	HORMAD2	chr22	30507785	+
79996	STAD	TCGA-MX-A666-01A	EIF2S2	chr20	32691268	-	HORMAD2	chr22	30514969	+
94346	SKCM	TCGA-D3-A1Q9-06A	EIF2S2	chr20	32681481	-	KCNB1	chr20	47927336	-
100913	HNSC	TCGA-CX-7082-01A	EIF2S2	chr20	32699902	-	LETM2	chr8	38245468	+
92699	Non-Cancer	TCGA-IN-8462-11A	EIF2S2	chr20	32699902	-	MTHFD1L	chr6	151330955	+
101913	HNSC	TCGA-BB-7866	EIF2S2	chr20	32686303	-	NCOA6	chr20	33331145	-
101913	HNSC	TCGA-BB-7866-01A	EIF2S2	chr20	32686304	-	NCOA6	chr20	33331145	-
90389	N/A	AA470596	EIF2S2	chr20	32686983	-	PDXDC1	chr16	15147666	-
92287	UCEC	TCGA-KP-A3W4-01A	EIF2S2	chr20	32691268	-	SKAP1	chr17	46266862	-
94726	N/A	BM837359	EIF2S2	chr20	32693234	-	TP53I11	chr11	44956305	-
102663	PRAD	TCGA-KK-A7B0	FAM101A	chr12	124458567	+	EIF2S2	chr20	32693351	-
102663	READ	TCGA-DC-6156	PPP4R1L	chr20	56884282	-	EIF2S2	chr20	32693351	-
102663	N/A	AA074990	PTCHD1	chrX	23355718	+	EIF2S2	chr20	32677237	+
102663	BRCA	TCGA-C8-A273	RALY	chr20	32581937	+	EIF2S2	chr20	32691371	-
102663	STAD	TCGA-BR-A4QI-01A	RALY	chr20	32619410	+	EIF2S2	chr20	32693351	-
102663	N/A	CB051177	RNF219	chr13	79228153	-	EIF2S2	chr20	32677249	+
102663	UCEC	TCGA-AJ-A3I9-01A	UBE4B	chr1	10093752	+	EIF2S2	chr20	32693351	-
102670	PRAD	TCGA-KK-A7B0-01A	ZNF664	chr12	124458567	+	EIF2S2	chr20	32693351	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	EIF2S2	0.0062855422949569	0.18
LUAD	EIF2S2	0.0194184847159643	0.52
KIRC	EIF2S2	0.0324994895974943	0.84
LUSC	EIF2S2	0.0337059430229103	0.84

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
STAD	EIF2S2	0.0172944213840682	0.54
KIRC	EIF2S2	0.0340142596246009	0.99
CESC	EIF2S2	0.0101540567575498	0.32
UCEC	EIF2S2	0.0279557770527186	0.84
SARC	EIF2S2	0.00207320600076442	0.068

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID	Disease Name	# PubMeds	Disease source
C0006142	Malignant neoplasm of breast	1	CTD_human
C0678222	Breast Carcinoma	1	CTD_human
C1257931	Mammary Neoplasms, Human	1	CTD_human
C4704874	Mammary Carcinoma, Human	1	CTD_human