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	Gene Summary
	Translation studies in PubMed
	Exon Skipping Events
	Expression
	Expression Regulation
	Associated Genes
	Protein 3D Structure
	Protein-Protein Interaction
	Mutations
	Prognostic Analysis
	Gender Association
	Age Association
	Related Drugs
	Related Diseases

Translation Factor: ASCC2 (NCBI Gene ID:84164)

Gene Summary

Gene Summary

Gene Information	Gene Name: ASCC2
	Gene ID: 84164
	Gene Symbol	ASCC2
	Gene ID	84164
	Gene Name	activating signal cointegrator 1 complex subunit 2
	Synonyms	ASC1p100\|p100
	Cytomap	22q12.2
	Type of Gene	protein-coding
	Description	activating signal cointegrator 1 complex subunit 2ASC-1 complex subunit P100trip4 complex subunit p100
	Modification date	20200313
	UniProtAcc	Q9H1I8

Child GO biological process term(s) under GO:0006412

GO ID	GO term
GO:0006414	Translational elongation
GO:0006412	Translation

Gene ontology of translaction factor with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	ASCC2	GO:0006355	regulation of transcription, DNA-templated	12077347

Inferred gene age of translation factor.

Gene	Inferred gene age group among (0 - 67.6], (67.6 - 355.7], (355.7 - 733], (733 - 1119.25], >1119.25
ASCC2	>1119.25

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Translation Studies in PubMed

We searched PubMed using 'ASCC2[title] AND translation [title] AND human.'

Gene	Title	PMID
ASCC2	.	.

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Exon Skipping Events

Skipped exons in TCGA and GTEx based on Ensembl gene isoform structure.
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
For more annotations, please visit our ExonSkipDB.

Open reading frame (ORF) analsis of exon skipping events based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	ORF
ENST00000307790	30196979	30197099	In-frame
ENST00000397771	30196979	30197099	In-frame
ENST00000307790	30197982	30198197	Frame-shift
ENST00000397771	30197982	30198197	Frame-shift
ENST00000307790	30204099	30204174	In-frame
ENST00000397771	30204099	30204174	In-frame
ENST00000307790	30218323	30218453	Frame-shift
ENST00000397771	30218323	30218453	Frame-shift
ENST00000307790	30221610	30221769	In-frame
ENST00000397771	30221610	30221769	In-frame
ENST00000397771	30228233	30228331	3UTR-3CDS
ENST00000397771	30230477	30230539	3UTR-3UTR

Exon skipping position in the amino acid sequence.

ENST	Exon skip start (DNA)	Exon Skip end (DNA)	Len(transcript seq)	Exon skip start (mRNA)	Exon Skip end (mRNA)	Len(amino acid seq)	Exon skip start (AA)	Exon Skip end (AA)
ENST00000307790	30196979	30197099	2810	1683	1802	757	523	562
ENST00000397771	30196979	30197099	2840	1747	1866	757	523	562
ENST00000307790	30204099	30204174	2810	948	1022	757	278	302
ENST00000397771	30204099	30204174	2840	1012	1086	757	278	302
ENST00000307790	30221610	30221769	2810	196	354	757	27	80
ENST00000397771	30221610	30221769	2840	260	418	757	27	80

Potentially (partially) lost protein functional features of UniProt.

UniProtAcc	Exon skip start (AA)	Exon Skip end (AA)	Function feature start (AA)	Function feature end (AA)	Functional feature type	Functional feature desc.
Q9H1I8	523	562	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
Q9H1I8	278	302	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
Q9H1I8	27	80	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
Q9H1I8	523	562	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
Q9H1I8	278	302	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
Q9H1I8	27	80	1	757	Chain	ID=PRO_0000064689;Note=Activating signal cointegrator 1 complex subunit 2
Q9H1I8	27	80	1	114	Alternative sequence	ID=VSP_011009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9H1I8	27	80	1	114	Alternative sequence	ID=VSP_011009;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9H1I8	27	80	28	80	Alternative sequence	ID=VSP_045878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9H1I8	27	80	28	80	Alternative sequence	ID=VSP_045878;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9H1I8	523	562	485	757	Alternative sequence	ID=VSP_011011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9H1I8	523	562	485	757	Alternative sequence	ID=VSP_011011;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303\|PubMed:14702039;Dbxref=PMID:14702039
Q9H1I8	523	562	546	546	Natural variant	ID=VAR_050677;Note=D->G;Dbxref=dbSNP:rs34833047
Q9H1I8	523	562	546	546	Natural variant	ID=VAR_050677;Note=D->G;Dbxref=dbSNP:rs34833047
Q9H1I8	523	562	526	526	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305
Q9H1I8	523	562	526	526	Sequence conflict	Note=K->N;Ontology_term=ECO:0000305;evidence=ECO:0000305

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Expression

Gene expression level across TCGA pancancer

Gene expression level across GTEx pantissue

Expression level of gene isoforms across TCGA pancancer

Expression level of gene isoforms across GTEx pantissue

Cancer(tissue) type-specific expression level of Translation factor using z-score distriution

Differential expression between tumor and matched normal (in the cancer types with more than 10 matched samples)

Cancer type	Translation factor	FC	adj.pval
LUAD	ASCC2	-3.16145158043654	0.000157924260899676

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Expression Regulation

Translation factor expression regulation through miRNA binding

Cancer type	Gene	miRNA	TargetScan binding score (Context++ score percentile)	Coefficient	Pvalue
KIRC	ASCC2	hsa-miR-320b	86	0.359177215189873	0.00123140438557783

Translation factor expression regulation through methylation in the promoter of Translation factor

Cancer type	Gene	methyl group b	methyl group a	DEG pval	avg methyl in b	avg methyl in a	avg exp in b	avg exp in a
BLCA	ASCC2	1	2	0.00137088518764957	0.177080792682928	0.234877024147727	-0.308749816811451	-0.0830274775654478

Translation factor expression regulation through methylation in the gene body of Translation factor (positive regulation)

Cancer type

Gene

methyl group b

methyl group a

DEG pval

avg methyl in b

avg methyl in a

avg exp in b

avg exp in a

Translation factor expression regulation through copy number variation of Translation factor

Cancer type	Gene	Coefficient	Pvalue
ESCA	ASCC2	-0.089036269	0.010169692
UVM	ASCC2	0.267694694	0.021824802

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Associated Genes

Strongly correlated genes belong to cellular important gene groups with ASCC2 (coefficient>0.8, pval<0.05, node color based on FC between tumor and matched normal). Significantly associated important genes in the individual cancer types. * Cell metabolism gene: cell metabolism genes from REACTOME (black edge), IUPHAR: drug target genes from IUPHAR (blue edge), Kinase: human kinase genes (brown edge), CGC: cancer gene census genes (orange edge), TSG: tumor suppresor genes (purple edge), Epifactor: epigenetic factors (light blue edge), TF: transcription factors (green)

Cancer type	Gene group	Translation factor	Correlated gene	Coefficient	Pvalue
KICH	CGC	ASCC2	SMARCB1	0.830930918	2.20E-24
KICH	Epifactor	ASCC2	SMARCB1	0.830930918	2.20E-24
KICH	TSG	ASCC2	SMARCB1	0.830930918	2.20E-24
THYM	Cell metabolism gene	ASCC2	TAZ	0.807162354	3.05E-29
THYM	Cell metabolism gene	ASCC2	ACAA1	0.813343718	5.26E-30
THYM	Cell metabolism gene	ASCC2	POLR2J	0.815031358	3.22E-30
THYM	Epifactor	ASCC2	ZNHIT1	0.801580003	1.41E-28
THYM	Epifactor	ASCC2	RBX1	0.809395587	1.63E-29
THYM	Epifactor	ASCC2	HIST2H2AC	0.847226335	9.25E-35
THYM	TF	ASCC2	ZNF444	0.803229577	9.02E-29
THYM	TF	ASCC2	USF2	0.807347267	2.89E-29
THYM	TF	ASCC2	DRAP1	0.811914926	7.94E-30
THYM	TSG	ASCC2	GLTSCR2	0.81148085	8.99E-30
UCS	Cell metabolism gene	ASCC2	TAZ	0.807162354	3.05E-29
UCS	Cell metabolism gene	ASCC2	ACAA1	0.813343718	5.26E-30
UCS	Cell metabolism gene	ASCC2	POLR2J	0.815031358	3.22E-30
UCS	Epifactor	ASCC2	ZNHIT1	0.801580003	1.41E-28
UCS	Epifactor	ASCC2	RBX1	0.809395587	1.63E-29
UCS	Epifactor	ASCC2	HIST2H2AC	0.847226335	9.25E-35
UCS	TF	ASCC2	ZNF444	0.803229577	9.02E-29
UCS	TF	ASCC2	USF2	0.807347267	2.89E-29
UCS	TF	ASCC2	DRAP1	0.811914926	7.94E-30
UCS	TSG	ASCC2	GLTSCR2	0.81148085	8.99E-30
UVM	Cell metabolism gene	ASCC2	PEMT	0.800419269	5.16E-19
UVM	Cell metabolism gene	ASCC2	CNOT3	0.802992252	3.28E-19
UVM	Cell metabolism gene	ASCC2	BSG	0.808126956	1.30E-19
UVM	Cell metabolism gene	ASCC2	PIK3R2	0.815161066	3.49E-20
UVM	Cell metabolism gene	ASCC2	SLC25A1	0.815566213	3.23E-20
UVM	Cell metabolism gene	ASCC2	GNB2	0.819309146	1.57E-20
UVM	Cell metabolism gene	ASCC2	PAFAH1B3	0.823548599	6.77E-21
UVM	Cell metabolism gene	ASCC2	TECR	0.823691807	6.58E-21
UVM	Cell metabolism gene	ASCC2	MED25	0.826844928	3.47E-21
UVM	Cell metabolism gene	ASCC2	DOHH	0.831635639	1.28E-21
UVM	Cell metabolism gene	ASCC2	MED16	0.842147748	1.28E-22
UVM	Cell metabolism gene	ASCC2	PRKCSH	0.857165926	3.49E-24
UVM	Cell metabolism gene	ASCC2	POLR2I	0.873467362	4.27E-26
UVM	CGC	ASCC2	CNOT3	0.802992252	3.28E-19
UVM	CGC	ASCC2	SMARCB1	0.805945129	1.93E-19
UVM	CGC	ASCC2	TFPT	0.806908992	1.62E-19
UVM	CGC	ASCC2	ASPSCR1	0.822525541	8.31E-21
UVM	CGC	ASCC2	SH3GL1	0.825428145	4.63E-21
UVM	Epifactor	ASCC2	SETD1A	0.800506811	5.08E-19
UVM	Epifactor	ASCC2	TRIM28	0.800880884	4.76E-19
UVM	Epifactor	ASCC2	SMARCB1	0.805945129	1.93E-19
UVM	Epifactor	ASCC2	TFPT	0.806908992	1.62E-19
UVM	Epifactor	ASCC2	RPS6KA4	0.82627801	3.89E-21
UVM	Epifactor	ASCC2	ATN1	0.827330904	3.14E-21
UVM	Epifactor	ASCC2	INO80E	0.831161658	1.41E-21
UVM	Epifactor	ASCC2	BRMS1	0.835377978	5.74E-22
UVM	Epifactor	ASCC2	TAF6	0.844260462	7.88E-23
UVM	Epifactor	ASCC2	ZGPAT	0.845273316	6.23E-23
UVM	Epifactor	ASCC2	TAF6L	0.846027494	5.23E-23
UVM	Epifactor	ASCC2	TAF10	0.847275219	3.90E-23
UVM	Epifactor	ASCC2	GATAD2A	0.853308503	9.14E-24
UVM	Epifactor	ASCC2	FBRS	0.857550342	3.17E-24
UVM	Epifactor	ASCC2	PELP1	0.875896937	2.10E-26
UVM	IUPHAR	ASCC2	MAPK7	0.800489177	5.09E-19
UVM	IUPHAR	ASCC2	SETD1A	0.800506811	5.08E-19
UVM	IUPHAR	ASCC2	ATP6V0C	0.800742356	4.87E-19
UVM	IUPHAR	ASCC2	TRIM28	0.800880884	4.76E-19
UVM	IUPHAR	ASCC2	CLCN7	0.802368529	3.66E-19
UVM	IUPHAR	ASCC2	NR1H2	0.802733868	3.43E-19
UVM	IUPHAR	ASCC2	ATP6V1F	0.806385624	1.78E-19
UVM	IUPHAR	ASCC2	SLC25A39	0.807707767	1.40E-19
UVM	IUPHAR	ASCC2	BSG	0.808126956	1.30E-19
UVM	IUPHAR	ASCC2	CSK	0.81341996	4.86E-20
UVM	IUPHAR	ASCC2	PIK3R2	0.815161066	3.49E-20
UVM	IUPHAR	ASCC2	LIMK1	0.815271463	3.42E-20
UVM	IUPHAR	ASCC2	SLC25A1	0.815566213	3.23E-20
UVM	IUPHAR	ASCC2	PRKD2	0.818201305	1.95E-20
UVM	IUPHAR	ASCC2	CAPN1	0.824368696	5.74E-21
UVM	IUPHAR	ASCC2	RPS6KA4	0.82627801	3.89E-21
UVM	IUPHAR	ASCC2	MAPK3	0.82745758	3.06E-21
UVM	IUPHAR	ASCC2	MAP3K11	0.831254044	1.39E-21
UVM	IUPHAR	ASCC2	PAK4	0.833929174	7.84E-22
UVM	IUPHAR	ASCC2	DYRK1B	0.83523094	5.92E-22
UVM	IUPHAR	ASCC2	MARK4	0.845621751	5.75E-23
UVM	IUPHAR	ASCC2	SCYL1	0.866480221	3.03E-25
UVM	Kinase	ASCC2	MAPK7	0.800489177	5.09E-19
UVM	Kinase	ASCC2	TRIM28	0.800880884	4.76E-19
UVM	Kinase	ASCC2	CSK	0.81341996	4.86E-20
UVM	Kinase	ASCC2	LIMK1	0.815271463	3.42E-20
UVM	Kinase	ASCC2	PRKD2	0.818201305	1.95E-20
UVM	Kinase	ASCC2	RPS6KA4	0.82627801	3.89E-21
UVM	Kinase	ASCC2	MAPK3	0.82745758	3.06E-21
UVM	Kinase	ASCC2	MAP3K11	0.831254044	1.39E-21
UVM	Kinase	ASCC2	PAK4	0.833929174	7.84E-22
UVM	Kinase	ASCC2	DYRK1B	0.83523094	5.92E-22
UVM	Kinase	ASCC2	MARK4	0.845621751	5.75E-23
UVM	Kinase	ASCC2	SCYL1	0.866480221	3.03E-25
UVM	TF	ASCC2	NR1H2	0.802733868	3.43E-19
UVM	TF	ASCC2	ZNF213	0.802893003	3.34E-19
UVM	TF	ASCC2	RFX1	0.808647223	1.18E-19
UVM	TF	ASCC2	PRR12	0.809759742	9.62E-20
UVM	TF	ASCC2	ZNF446	0.811537118	6.92E-20
UVM	TF	ASCC2	ZNF579	0.815467475	3.29E-20
UVM	TF	ASCC2	RELA	0.817013277	2.45E-20
UVM	TF	ASCC2	ZNF777	0.829819637	1.87E-21
UVM	TF	ASCC2	CAMTA2	0.832739545	1.01E-21
UVM	TF	ASCC2	ZNF574	0.840456278	1.87E-22
UVM	TF	ASCC2	ZNF444	0.842960997	1.06E-22
UVM	TF	ASCC2	ZGPAT	0.845273316	6.23E-23
UVM	TF	ASCC2	ZNF408	0.846913875	4.25E-23
UVM	TF	ASCC2	ZNF787	0.848102808	3.21E-23
UVM	TF	ASCC2	GATAD2A	0.853308503	9.14E-24
UVM	TF	ASCC2	FIZ1	0.863144175	7.42E-25
UVM	TF	ASCC2	ZNF358	0.863218558	7.28E-25
UVM	TF	ASCC2	ZNF628	0.878122197	1.09E-26
UVM	TF	ASCC2	ZNF414	0.879262766	7.69E-27
UVM	TF	ASCC2	ZBTB45	0.882922852	2.49E-27
UVM	TF	ASCC2	SOX10	0.89746895	1.87E-29
UVM	TSG	ASCC2	CNOT3	0.802992252	3.28E-19
UVM	TSG	ASCC2	STUB1	0.805798022	1.98E-19
UVM	TSG	ASCC2	SMARCB1	0.805945129	1.93E-19
UVM	TSG	ASCC2	BRMS1	0.835377978	5.74E-22
UVM	TSG	ASCC2	RNH1	0.835421619	5.68E-22
UVM	TSG	ASCC2	TSSC4	0.839794967	2.17E-22
UVM	TSG	ASCC2	SCYL1	0.866480221	3.03E-25
UVM	TSG	ASCC2	GABARAP	0.873517397	4.21E-26

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Protein structure

Protein 3D structure
Visit iCn3D.

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Protein-Protein Interaction

Protein-protein interaction networks
* Overlap between up-regulated DEGs (log2FC<-1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

Overlap between down-regulated DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network (center: Translation factor, node: DEGs, edges: weighted by -log2(adj.P))

* Edge colors based on TCGA cancer types.

* Overlap between DEGs (log2FC>1 and adj.P<0.05) and STRING PPI network per cancer (center: Translation factor, node: DEGs, node color: log2FC, edges: weighted by -log2(adj.P))

Cancer type	Translation factor	Interacting protein coding gene	FC	adj.pval
KICH	ASCC2	PPIL3	1.99874556649823	0.000102996826171875
KICH	ASCC2	CWF19L1	1.78539738561058	0.000187873840332031
COAD	ASCC2	ASCC1	-1.08291850716374	0.00028228759765625
LIHC	ASCC2	CWF19L1	-1.11781197315414	0.000589136168005134
PRAD	ASCC2	PPM1F	-2.20930198161812	0.000765420708634225
ESCA	ASCC2	CWF19L1	-2.20178361726075	0.001953125
LIHC	ASCC2	CRNKL1	-1.16471145122566	0.00235963995691637
KIRP	ASCC2	CRNKL1	-2.65029665761533	0.00239070039242506
HNSC	ASCC2	ASCC1	-1.15387951517859	0.00302236390302824
STAD	ASCC2	PRCC	-4.88878917772529	0.00315681146457791
STAD	ASCC2	CRNKL1	-1.14386551799857	0.00779616041108966
ESCA	ASCC2	ASCC3	2.18518498783614	0.009765625
HNSC	ASCC2	PPIL3	1.15220888188296	0.0107492202567602
KIRP	ASCC2	TRIP4	-1.39464355922267	0.0124990218318999
ESCA	ASCC2	PRCC	-1.05463335729824	0.0185546875
LUSC	ASCC2	PPIL3	-1.85802560121121	0.0396404633591005
KICH	ASCC2	PRCC	1.21610055474649	2.98023223876953e-07
PRAD	ASCC2	CRNKL1	1.09513810600514	3.19004982336673e-06
PRAD	ASCC2	ASCC1	1.85803625084882	3.62784175771099e-05
LUAD	ASCC2	CRNKL1	-1.74957045604031	3.68051585654523e-05
LIHC	ASCC2	PPM1F	-2.84454587444051	4.13049286581462e-09
KIRC	ASCC2	ASCC1	1.17322821298021	4.78942706319417e-05
KIRP	ASCC2	ASCC3	-5.24180349883123	4.97791916131974e-07
BRCA	ASCC2	CRNKL1	1.64642525073749	5.12920484945736e-16
LUSC	ASCC2	PPM1F	-2.42578140514466	5.43966600483641e-07
LUAD	ASCC2	ASCC1	-3.45972551520068	6.05809956862828e-05
BRCA	ASCC2	ASCC3	2.06358786352366	7.50752312589849e-07
LIHC	ASCC2	TRIP4	-2.05741049955716	8.10485983396854e-07
KICH	ASCC2	TRIP4	-2.18314831686334	8.80360603332519e-05
THCA	ASCC2	ASCC3	-2.23628356566653	8.91332468972732e-06

Protein-protein interactors with this translation factor (BIOGRID-3.4.160)

PPI interactors with ASCC2

CUTC, CKAP4, DEAF1, ELAC2, FAF1, GFER, IGSF9, LPL, GNL3, PIK3CD, URM1, RADIL, GTF3C1, FUNDC2, IMMT, MYH9, PIN4, PJA1, POLDIP2, SNRPB, TBC1D17, KDM1A, ASS1, FBP1, POLA2, OLA1, MED31, RPA1, EEF1D, RPLP1, SNW1, PCBD2, RNF11, GADD45A, MAP3K1, ALKBH3, ASCC1, RPS19, ASCC3, GPC4, TRIP4, NTRK1, CC2D2A, CEP128, HDAC1, VCL, NIPSNAP1, EMC2, PAPD5, ENTHD2, SPC24, BAG6, Bub1, Gspt1, SMURF1, CSRP1, UBC, CHD3, ESR2, RECQL4, MB21D1, SASH1, DDX60, NFX1, BRD7, KATNAL1, PRPF18, PLEKHA4, MIB1, ESR1, HSCB, PAIP1, TRIM56, GTPBP1, TRIM25, nsp2ab, DNAJA2, TULP3, DDRGK1, RPS20, SMAD4, RPS6, RPS3, DUSP16, HIST1H2AM, ABT1, NOG, PABPC5, RPS13, HNRNPCL2, DGCR2, H2AFB2, DGKZ, RPL26L1, PURG, RBM4B, AMY1C, RPS10, GPKOW, METTL21B, SIRT6,

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Mutations

Clinically associated variants from ClinVar.

Gene

Chr

Position

RefSeq

VarSeq

RefSeeq

VarType

Pathogenic

Disease

VarInfo

nsSNVs with sample frequency (size of circle) from TCGA 33 cancers.

SNVs and Indels

Gene	Cancer type	Chromosome	Start	End	RefSeeq	MutSeq	Mutation type	AAchange	# samples
ASCC2	PRAD	chr22	30221628	30221628	C	T	Missense_Mutation	p.D75N	4
ASCC2	ESCA	chr22	30221678	30221678	C	T	Missense_Mutation	p.R58H	3
ASCC2	PAAD	chr22	30212055	30212055	G	T	Silent	p.I183I	3
ASCC2	UCEC	chr22	30185169	30185169	G	A	Missense_Mutation	p.R703W	3
ASCC2	BRCA	chr22	30189366	30189366	G	A	Silent	p.D634	3
ASCC2	BRCA	chr22	30189408	30189408	G	A	Silent	p.Y620	3
ASCC2	BRCA	chr22	30197090	30197090	T	C	Silent	p.K526	3
ASCC2	STAD	chr22	30221167	30221167	G	T	Missense_Mutation		2
ASCC2	BRCA	chr22	30210708	30210708	T	G	Missense_Mutation	p.N220H	2
ASCC2	STAD	chr22	30228273	30228273	C	A	Missense_Mutation		2
ASCC2	SARC	chr22	30188523	30188523	G	T	Missense_Mutation		2
ASCC2	UCEC	chr22	30189432	30189432	G	A	Silent	p.Y612	2
ASCC2	STAD	chr22	30221167	30221167	G	T	Missense_Mutation	p.A107D	2
ASCC2	ESCA	chr22	30189349	30189349	C	A	Missense_Mutation		2
ASCC2	PAAD	chr22	30186501	30186501	C	A	Nonsense_Mutation	p.E687*	2
ASCC2	UCEC	chr22	30197098	30197098	C	A	Nonsense_Mutation	p.E524*	2
ASCC2	STAD	chr22	30228273	30228273	C	A	Missense_Mutation	p.K14N	2
ASCC2	BLCA	chr22	30188508	30188508	G	A	Nonsense_Mutation	p.Q646*	2
ASCC2	ESCA	chr22	30221678	30221678	C	T	Missense_Mutation		2
ASCC2	UCEC	chr22	30209515	30209515	A	C	Missense_Mutation	p.V246G	2
ASCC2	STAD	chr22	30221652	30221652	C	T	Missense_Mutation	p.D67N	2
ASCC2	BLCA	chr22	30198101	30198101	C	T	Missense_Mutation	p.E484K	2
ASCC2	LIHC	chr22	30197074	30197074	G	-	Frame_Shift_Del	p.L533fs	2
ASCC2	UCEC	chr22	30209527	30209527	A	C	Nonsense_Mutation	p.L242*	2
ASCC2	STAD	chr22	30221642	30221642	A	C	Missense_Mutation	p.L70R	2
ASCC2	BLCA	chr22	30198142	30198142	G	A	Missense_Mutation	p.S470F	2
ASCC2	LIHC	chr22	30200730	30200730	G	-	Frame_Shift_Del	p.P417fs	2
ASCC2	TGCT	chr22	30200713	30200713	G	A	Missense_Mutation		2
ASCC2	UCEC	chr22	30221125	30221125	C	T	Missense_Mutation	p.R121Q	2
ASCC2	STAD	chr22	30210714	30210714	C	T	Missense_Mutation	p.G218R	2
ASCC2	LIHC	chr22	30218403	30218403	G	T	Missense_Mutation		2
ASCC2	UCEC	chr22	30221667	30221667	C	T	Missense_Mutation	p.V62I	2
ASCC2	SKCM	chr22	30202214	30202214	G	A	Missense_Mutation	p.S384L	2
ASCC2	STAD	chr22	30185160	30185160	T	C	Missense_Mutation	p.S706G	2
ASCC2	CHOL	chr22	30186459	30186459	C	A	Missense_Mutation		2
ASCC2	SKCM	chr22	30202521	30202521	G	A	Silent	p.F346F	2
ASCC2	BLCA	chr22	30185085	30185085	C	A	Nonsense_Mutation	p.E731*	2
ASCC2	STAD	chr22	30189452	30189452	G	A	Missense_Mutation	p.P606S	2
ASCC2	BLCA	chr22	30200815	30200815	C	T	Missense_Mutation	p.E389K	2
ASCC2	KIRC	chr22	30189476	30189476	G	T	Missense_Mutation	p.P598T	2
ASCC2	CHOL	chr22	30186459	30186459	C	A	Splice_Site	p.G701_splice	2
ASCC2	LIHC	chr22	30202864	30202865	GA	-	Frame_Shift_Del	p.S313fs	2
ASCC2	ESCA	chr22	30189349	30189349	C	A	Missense_Mutation	p.R640M	2
ASCC2	STAD	chr22	30188437	30188437	G	A	Silent	p.D669D	2
ASCC2	LIHC	chr22	30218403	30218403	G	T	Missense_Mutation	p.F154L	2
ASCC2	BLCA	chr22	30218396	30218396	C	A	Missense_Mutation		1
ASCC2	SKCM	chr22	30209472	30209472	C	T	Silent	p.L260L	1
ASCC2	KIRP	chr22	30204118	30204118	C	A	Missense_Mutation		1
ASCC2	READ	chr22	30186483	30186483	G	A	Missense_Mutation	p.R617C	1
ASCC2	STAD	chr22	30221725	30221725	C	T	Silent	p.P42P	1
ASCC2	COAD	chr22	30198025	30198025	C	T	Missense_Mutation	p.R433Q	1
ASCC2	LUAD	chr22	30197042	30197042	A	G	Silent	p.N542N	1
ASCC2	SKCM	chr22	30186469	30186469	G	A	Silent	p.L621L	1
ASCC2	BLCA	chr22	30186466	30186466	G	A	Silent		1
ASCC2	ESCA	chr22	30189408	30189408	G	T	Nonsense_Mutation	p.Y620*	1
ASCC2	PAAD	chr22	30186501	30186501	C	A	Nonsense_Mutation	p.E687X	1
ASCC2	SKCM	chr22	30209463	30209463	G	A	Silent	p.F263F	1
ASCC2	KIRP	chr22	30198153	30198153	C	A	Silent		1
ASCC2	LIHC	chr22	30204137	30204137	C	A	Nonsense_Mutation	p.E291*	1
ASCC2	STAD	chr22	30185132	30185132	C	T	Missense_Mutation	p.R715Q	1
ASCC2	COAD	chr22	30200649	30200649	G	A	Missense_Mutation	p.P368L	1
ASCC2	LUAD	chr22	30221692	30221692	C	A	Missense_Mutation	p.E53D	1
ASCC2	SKCM	chr22	30186482	30186482	C	G	Missense_Mutation	p.R617P	1
ASCC2	BLCA	chr22	30198080	30198080	G	A	Silent	p.L491L	1
ASCC2	SKCM	chr22	30198133	30198133	G	A	Missense_Mutation	p.S473F	1
ASCC2	KIRP	chr22	30210709	30210709	G	T	Silent		1
ASCC2	LIHC	chr22	30221114	30221115	-	A	Frame_Shift_Ins	p.H125fs	1
ASCC2	SARC	chr22	30228307	30228307	G	T	Missense_Mutation		1
ASCC2	STAD	chr22	30218382	30218382	G	A	Silent	p.I161I	1
ASCC2	ACC	chr22	30197089	30197089	G	A	Missense_Mutation	p.P527S	1
ASCC2	COAD	chr22	30210663	30210664	-	G	Frame_Shift_Ins	p.S159fs	1
ASCC2	LUAD	chr22	30200706	30200706	C	T	Missense_Mutation	p.G425E	1
ASCC2	SKCM	chr22	30185011	30185011	G	A	Silent	p.I755I	1
ASCC2	PAAD	chr22	30186501	30186501	C	A	Nonsense_Mutation		1
ASCC2	SKCM	chr22	30200727	30200727	G	A	Missense_Mutation	p.S418L	1
ASCC2	KIRP	chr22	30212012	30212012	G	T	Missense_Mutation		1
ASCC2	LIHC	chr22	30221170	30221171	-	C	Frame_Shift_Ins	p.G106fs	1
ASCC2	SARC	chr22	30198172	30198172	C	T	Missense_Mutation		1
ASCC2	STAD	chr22	30185156	30185156	G	T	Nonsense_Mutation	p.S707*	1
ASCC2	BLCA	chr22	30198080	30198080	G	A	Silent		1
ASCC2	COAD	chr22	30212010	30212010	C	T	Silent	p.L122L	1
ASCC2	LUAD	chr22	30218423	30218423	C	G	Missense_Mutation	p.E148Q	1
ASCC2	SKCM	chr22	30218364	30218364	G	A	Silent	p.L167L	1
ASCC2	ESCA	chr22	30188474	30188474	T	C	Missense_Mutation	p.Q657R	1
ASCC2	PAAD	chr22	30212055	30212055	G	T	Silent		1
ASCC2	SKCM	chr22	30186482	30186482	C	G	Missense_Mutation	p.R693P	1
ASCC2	CESC	chr22	30189461	30189461	C	T	Missense_Mutation		1
ASCC2	LIHC	chr22	30218392	30218392	A	G	Missense_Mutation		1
ASCC2	SARC	chr22	30209479	30209479	G	T	Missense_Mutation		1
ASCC2	STAD	chr22	30221196	30221196	A	C	Nonsense_Mutation	p.Y97*	1
ASCC2	BLCA	chr22	30198101	30198101	C	T	Missense_Mutation		1
ASCC2	COAD	chr22	30218370	30218370	G	A	Silent	p.C89C	1
ASCC2	LUAD	chr22	30202280	30202280	C	A	Splice_Site		1
ASCC2	SKCM	chr22	30204123	30204123	C	T	Silent	p.K295K	1
ASCC2	ESCA	chr22	30189408	30189408	G	T	Nonsense_Mutation	p.Y620X	1
ASCC2	PRAD	chr22	30218380	30218380	A	G	Missense_Mutation	p.L162P	1
ASCC2	SKCM	chr22	30186469	30186469	G	A	Silent	p.L697L	1
ASCC2	CESC	chr22	30198042	30198042	G	T	Missense_Mutation		1
ASCC2	LIHC	chr22	30230515	30230515	A	G	Missense_Mutation		1
ASCC2	SARC	chr22	30218426	30218426	C	G	Missense_Mutation	p.G147R	1
ASCC2	BLCA	chr22	30198142	30198142	G	A	Missense_Mutation		1
ASCC2	COAD	chr22	30218385	30218385	C	A	Missense_Mutation	p.K160N	1
ASCC2	LUAD	chr22	30218359	30218359	C	T	Missense_Mutation	p.G169E	1
ASCC2	SKCM	chr22	30189431	30189431	C	T	Missense_Mutation	p.E613K	1
ASCC2	SKCM	chr22	30197997	30197997	G	A	Silent	p.D518D	1
ASCC2	BLCA	chr22	30186505	30186505	C	G	Silent	p.L685L	1
ASCC2	ESCA	chr22	30189349	30189349	C	A	Splice_Site	p.R640_splice	1
ASCC2	CESC	chr22	30189461	30189461	C	T	Missense_Mutation	p.E603K	1
ASCC2	LIHC	chr22	30221094	30221094	G	-	Frame_Shift_Del	p.S131fs	1
ASCC2	SKCM	chr22	30197997	30197997	G	A	Silent	p.D442D	1
ASCC2	TGCT	chr22	30221120	30221120	C	T	Missense_Mutation		1
ASCC2	BLCA	chr22	30200632	30200633	-	-	Frame_Shift_Ins		1
ASCC2	COAD	chr22	30221155	30221155	T	C	Missense_Mutation	p.E58G	1
ASCC2	LUSC	chr22	30189468	30189468	C	T	Silent	p.Q600Q	1
ASCC2	SKCM	chr22	30202864	30202864	G	A	Missense_Mutation	p.S313F	1
ASCC2	PRAD	chr22	30202490	30202490	A	C	Missense_Mutation	p.L357V	1
ASCC2	BLCA	chr22	30221764	30221764	G	C	Silent	p.P29P	1
ASCC2	HNSC	chr22	30198121	30198121	T	C	Missense_Mutation		1
ASCC2	LIHC	chr22	30212015	30212015	T	C	Missense_Mutation		1
ASCC2	LIHC	chr22	30221158	30221158	G	-	Frame_Shift_Del	p.P110fs	1
ASCC2	SKCM	chr22	30200727	30200727	G	A	Missense_Mutation	p.S342L	1
ASCC2	THCA	chr22	30200761	30200761	C	G	Missense_Mutation		1
ASCC2	BLCA	chr22	30186505	30186505	C	G	Silent		1
ASCC2	COAD	chr22	30230543	30230543	A	-	Intron	.	1
ASCC2	LUSC	chr22	30198081	30198081	G	A	Silent	p.C490C	1
ASCC2	SKCM	chr22	30188516	30188516	G	A	Missense_Mutation	p.T643I	1
ASCC2	PRAD	chr22	30200815	30200815	C	A	Nonsense_Mutation	p.E389*	1
ASCC2	STAD	chr22	30221196	30221196	A	C	Nonsense_Mutation	p.Y97X	1
ASCC2	HNSC	chr22	30198121	30198121	T	C	Missense_Mutation	p.D477G	1
ASCC2	CHOL	chr22	30186459	30186459	C	A	Missense_Mutation	p.G701W	1
ASCC2	LIHC	chr22	30202864	30202865	GA	-	Frame_Shift_Del		1
ASCC2	LIHC	chr22	30221171	30221171	C	-	Frame_Shift_Del	p.V106fs	1
ASCC2	SKCM	chr22	30202521	30202521	G	A	Silent	p.F270F	1
ASCC2	THYM	chr22	30212005	30212005	G	T	Missense_Mutation	p.T200N	1
ASCC2	BLCA	chr22	30221764	30221764	G	C	Silent		1
ASCC2	COAD	chr22	30200658	30200658	G	T	Nonsense_Mutation	p.S441X	1
ASCC2	LUSC	chr22	30189459	30189459	C	G	Missense_Mutation	p.E603D	1
ASCC2	SKCM	chr22	30209462	30209462	G	A	Missense_Mutation	p.P264S	1
ASCC2	PRAD	chr22	30185114	30185114	C	T	Missense_Mutation	p.R721H	1
ASCC2	SKCM	chr22	30202248	30202248	C	T	Missense_Mutation	p.V373M	1
ASCC2	LIHC	chr22	30202839	30202839	C	A	Missense_Mutation	p.E321D	1
ASCC2	SKCM	chr22	30209463	30209463	G	A	Silent	p.F187F	1
ASCC2	UCEC	chr22	30186517	30186517	G	T	Missense_Mutation	p.D681E	1
ASCC2	BLCA	chr22	30200815	30200815	C	T	Missense_Mutation		1
ASCC2	LUSC	chr22	30185168	30185168	C	T	Missense_Mutation	p.R703Q	1
ASCC2	SKCM	chr22	30209479	30209479	G	A	Missense_Mutation	p.A258V	1
ASCC2	READ	chr22	30209520	30209520	G	A	Silent	p.D168D	1
ASCC2	BLCA	chr22	30186466	30186466	G	A	Silent	p.A698A	1
ASCC2	KIRP	chr22	30188510	30188510	G	C	Missense_Mutation	p.P645R	1
ASCC2	CHOL	chr22	30212002	30212002	A	G	Missense_Mutation	p.I201T	1
ASCC2	LIHC	chr22	30204137	30204137	C	A	Missense_Mutation		1
ASCC2	SKCM	chr22	30202248	30202248	C	T	Missense_Mutation	p.V297M	1
ASCC2	UCEC	chr22	30188429	30188429	G	C	Missense_Mutation	p.A672G	1

Copy number variation (CNV) of ASCC2
* Click on the image to open the original image in a new window.

Fusion gene breakpoints (product of the structural variants (SVs)) across ASCC2
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion genes with this translation factor from FusionGDB2.0.

FusionGDB2 ID	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
102373	N/A	BI858341	ASCC2	chr22	30218629	+	ANXA2	chr15	60639535	+
65141	N/A	CF141338	ASCC2	chr22	30228593	+	ARHGEF4	chr2	131805449	+
103161	N/A	BF899598	ASCC2	chr22	30198104	+	ASCC2	chr22	30198020	-
88811	N/A	CF139510	ASCC2	chr22	30228594	+	B4GALT5	chr20	48250738	-
82651	OV	TCGA-13-0760	ASCC2	chr22	30221075	-	CCNL2	chr1	1326245	-
48282	N/A	BM016415	ASCC2	chr22	30218630	+	CFL2	chr14	35181220	+
79380	N/A	CD652508	ASCC2	chr22	30218629	+	CHD1L	chr1	146753470	-
62305	N/A	BI493656	ASCC2	chr22	30228739	-	DNA2	chr10	70220546	+
93484	N/A	AW177744	ASCC2	chr22	30188500	+	EZR	chr6	159191893	+
101853	N/A	AK126172	ASCC2	chr22	29978389	-	FOXP4	chr6	41569325	+
22407	N/A	CF122313	ASCC2	chr22	30228593	+	IRX4	chr5	1877527	+
95621	N/A	AK093581	ASCC2	chr22	30195484	-	LAMTOR3	chr4	100815585	-
68585	CESC	TCGA-VS-A9U5-01A	ASCC2	chr22	30230478	-	MTMR3	chr22	30353025	+
88859	N/A	CB049144	ASCC2	chr22	30204796	-	PCSK7	chr11	117075508	-
98633	N/A	BP432685	ASCC2	chr22	30184600	-	ROBO1	chr3	79559727	-
101963	N/A	CF140549	ASCC2	chr22	30228593	+	RUVBL1	chr3	127799806	+
80397	N/A	CF144963	ASCC2	chr22	30228592	+	SENP3-EIF4A1	chr17	7481907	+
98358	PAAD	TCGA-IB-AAUQ-01A	ASCC2	chr22	30234167	-	SF3A1	chr22	30736801	-
96719	N/A	AX381472	ASCC2	chr22	30218628	+	SNRPC	chr6	34741571	-
103161	N/A	BP394862	CD74	chr5	149781430	-	ASCC2	chr22	30185156	-
103161	N/A	BI493948	DDX17	chr22	38879443	-	ASCC2	chr22	30198475	+
103161	N/A	BI493655	DNA2	chr10	70220546	-	ASCC2	chr22	30228739	+
103161	LUAD	TCGA-44-A4SU-01A	EIF3L	chr22	38251651	-	ASCC2	chr22	30228331	-
103161	N/A	BF342443	RLF	chr1	40706591	+	ASCC2	chr22	30216902	+
103161	N/A	BF217955	SNAPC5	chr15	66788333	+	ASCC2	chr22	30167952	+
103161	OV	TCGA-09-2044-01B	THOC5	chr22	29939418	-	ASCC2	chr22	30212062	-
103161	N/A	CF122827	TIPIN	chr15	66628459	+	ASCC2	chr22	30228593	-
103161	BRCA	TCGA-C8-A135-01A	TTC28	chr22	28692186	-	ASCC2	chr22	30186537	-
103161	N/A	BD311018	UBE2J1	chr6	90036859	-	ASCC2	chr22	30218630	-
103161	N/A	BG032932	YAP1	chr11	102104152	+	ASCC2	chr22	30216902	+
103161	BLCA	TCGA-G2-AA3B-01A	ZMAT5	chr22	30162938	-	ASCC2	chr22	30189665	-
103161	GBM	TCGA-41-2572-01A	ZMAT5	chr22	30162861	-	ASCC2	chr22	30186537	-
103161	GBM	TCGA-41-2572-01A	ZMAT5	chr22	30162938	-	ASCC2	chr22	30186537	-
103161	N/A	BI861699	ZMAT5	chr22	30153775	+	ASCC2	chr22	30202997	+
103185	BRCA	TCGA-A8-A094	ZNRF3	chr22	29280054	+	ASCC2	chr22	30221769	-
103185	BRCA	TCGA-A8-A094-01A	ZNRF3	chr22	29280053	+	ASCC2	chr22	30221245	-
103185	BRCA	TCGA-A8-A094-01A	ZNRF3	chr22	29280053	+	ASCC2	chr22	30221768	-
103185	BRCA	TCGA-A8-A094-01A	ZNRF3	chr22	29280054	+	ASCC2	chr22	30221246	-

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Prognostic Analysis

Kaplan-Meier plots with logrank tests of overall survival (OS)

Cancer type

Translation factor

Coefficent

Hazard ratio

Wald test pval

Likelihool ratio pval

Logrank test pval

# samples

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Translation factor and Gender

Differential gene expression between female and male. (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
LUAD	ASCC2	0.002926323877862	0.082
KIRP	ASCC2	0.00701276766178465	0.19
CHOL	ASCC2	0.0291361736511418	0.76

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Translation factor and Age

Differential gene expression between young and old age groups (Wilcoxon test, pval<0.05)

Cancer type	Translation factor	pval	adj.p
KIRP	ASCC2	0.0212987745902601	0.6
LGG	ASCC2	0.00011002075464231	0.0036
PAAD	ASCC2	0.0143671083179988	0.43
ACC	ASCC2	0.0187649806862604	0.54
THYM	ASCC2	0.00545833223871535	0.17
SARC	ASCC2	0.00072624465806711	0.023

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Related Drugs

Drugs targeting genes involved in this translation factor.
(DrugBank Version 5.1.8 2021-05-08)

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases

Diseases associated with this translation factor.
(DisGeNet 4.0)

Disease ID

Disease Name

# PubMeds

Disease source